Circulating cytokine measurements by protein chips in patients with acute coronary syndrome
10.3321/j.issn:0253-3758.2008.03.008
- VernacularTitle:蛋白芯片法联检急性冠状动脉综合征患者血中细胞因子的意义
- Author:
Hua MAO
1
;
Ting-Zhu LIU
;
Mei WEN
;
Jing-Jing CHEN
;
Ling LI
;
Jin-Kun ZHU
Author Information
1. 贵州省贵阳市第一人民医院
- Keywords:
Coronary disease;
Cytokines;
Protein chips
- From:
Chinese Journal of Cardiology
2008;36(3):219-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the feasibility of measuring multiple circulating cytokines by protein chips in patients with acute coronary syndrome(ACS).Methods Circulating cytokines were determined bv protein chips in 50 control cases and 104 ACS cases of unstable angina pectoris(UA,n=50)and acute myocardial infarction(AMI,n=54)cases.Results The levels of serum MMP-9,sCD40L,CRP,IL-6,H-FABP,cTnⅠ and plasma IL-8,NT-proBNP,sVCAM-1,ET-1 in ACS group were significantly higher than those in the control group(all P＜0.01).Serum H-FABP and cTnⅠ were significantly higher in AMI patients than in UA patients(P＜0.01).Serum MMP-9,sCD40L,CRP,IL-6 and plasma sVCAM-1,ET-1 tended to be higher in AMI patients as compared to UA patients(all P＞0.05).Serum MMP-9,sCD40L.and H-FABP were positively correlated with the severity of angina(r=0.653,r=0.745,r=0.933,P＜0.01,respectively).Serum MMP-9,sCD40L,and H-FABP increased in proportion to the levels of Braunwald angina classes in UA patients(angina class Ⅰ＜angina class Ⅱ＜angina class Ⅲ,P＜0.01).Conclusions Circulating cytokines were significantly increased in ACS patients and positively correlated to Braunwald angina classes in UA patients.
