Relationship between Ghrelin polymorphism and serum lipoprotein levels in Han Chinese with or without coronary heart disease risk factors.
- Author:
Xuan XIE
1
;
Jing ZHANG
;
Yu-huan WANG
;
Jun-hong WANG
;
Chun-hong ZHANG
;
Hong-yan NI
;
Xiao-hong YUAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; ethnology; genetics; Cholesterol, HDL; blood; Coronary Disease; genetics; Female; Gene Frequency; Genotype; Ghrelin; genetics; Humans; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Risk Factors
- From: Chinese Journal of Cardiology 2008;36(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between polymorphism of Ghrelin gene and serum levels of lipoprotein in Han Chinese with or without coronary heart disease (CHD) risk factors.
METHODSPCR restriction fragment length polymorphism assay was used to detect the distribution of genotypes of Ghrelin gene in 225 Han Chinese (40 to 69 years-old) with CHD risk factors, 78 subjects without CHD risk factors served as normal controls. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein (VLDL) were measured to analyze the relationship with the polymorphism of Ghrelin gene.
RESULTSGhrelin genotype frequencies of AA, AG, GG (0.975, 0.025, 0.00 in control group and 0.956, 0.040, 0.004 in the high-risk group, all P > 0.05) as well as the allele frequencies of A, G (0.987, 0.013 in control group and 0.976, 0.024 in the high-risk group, all P > 0.05) were similar between the groups. HDL-C levels of the Arg/Gln carriers were significantly lower than those of Arg/Arg carriers in control group and in the high-risk group (all P < 0.05).
CONCLUSIONArg/Gln carriers were associated lower HDL-C levels in Han Chinese.
