Relationship between Ghrelin polymorphism and serum lipoprotein levels in Han Chinese with or without coronary heart disease risk factors
10.3321/j.issn:0253-3758.2008.04.005
- VernacularTitle:西安地区汉族人群Ghrelin基因多态性与高密度脂蛋白胆固醇的关系
- Author:
Xuan XIE
1
;
Jing ZHANG
;
Yu-Huan WANG
;
Jun-Hong WANG
;
Chun-Hong ZHANG
;
Hong-Yan NI
;
Xiao-Hong YUAN
Author Information
1. 西安交通大学医学院附属第二医院
- Keywords:
Genes;
Lipoproteins,HDL;
Han nationality
- From:
Chinese Journal of Cardiology
2008;36(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphism of Ghrelin gene and serum levels of lipoprotein in Han Chinese with or without coronary heart disease(CHD)risk factors.Methods PCR restriction fragment length polymorphism assay was used to detect the distribution of genotypes of Ghrelin gene in 225 Han Chinese(40 to 69 years-old)with CHD risk factors,78 subiects without CHD risk factors served as normal controls.Serum levels of total cholesterol(TC), triglyceride (TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C)and very low-density lipoprotein(VLDL)were measured to analyze the relationship with the polymorphism of Ghrelin gene.Results Ghrelin genotype frequencies of AA,AG,GG(0.975,0.025,0.00 in control group and 0.956,0.040,0.004 in the high-risk group,all P＞0.05)as well as the allele frequencies of A,G (0.987,0.013 in control group and 0.976,0.024 in the high-risk group,all P＞0.05)were similar between the groups.HDL-C levels of the Arg/Gln carrieYs were significantly lower than those of Arg/Arg carriers in control group and in the high-risk group(all P＜0.05).Conclusion Arg/Gln carriers were associated lower HDL-C levels in Han Chinese.
