Detection of gene mutations of SCN5A in 7 patients with Brugada syndrome.
- Author:
Bin-bin YUAN
1
;
Qi-jun SHAN
;
Bing YANG
;
Ming-long CHEN
;
Jian-gang ZOU
;
Chun CHEN
;
Dong-jie XU
;
Ke-jiang CAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Brugada Syndrome; genetics; DNA Mutational Analysis; Exons; Humans; Male; Middle Aged; Muscle Proteins; genetics; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Sodium Channels; genetics
- From: Chinese Journal of Cardiology 2008;36(5):404-407
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEBrugada syndrome is linked to sodium channel mutations and could induce arrhythmias that even lead to sudden death. The purpose of this study was to detect if there was gene mutation of SCN5A in 7 patients with Brugada syndrome and explore the molecular genetic characteristics of this disease.
METHODGenomic DNA was extracted from peripheral blood of all 7 patients with Brugada syndrome and 41 pairs of PCR primers were designed to amplify all the 28 exons of SCN5A.
RESULTThere was no novel mutation in exons of Gene SCN5A in these patients with Brugada syndrome.
CONCLUSIONBrugada syndrome might associated gene mutation or other mechanisms independent of SCN5A gene mutation.
