Dobutamine stress echocardiography in patients with hypertrophic cardiomyopathy
10.3321/j.issn:0253-3758.2008.05.009
- VernacularTitle:多巴酚丁胺在肥厚型心肌病激发试验的应用
- Author:
Jian-Song YUAN
1
;
Shu-Bin QIAO
;
Shi-Jie YOU
;
Wei-Xian YANG
;
Xiu-Zhang L(U)
;
Feng-Huan HU
;
Run-Lin GAO
;
Ji-Lin CHEN
;
Yue-Jin YANG
Author Information
1. 中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院
- Keywords:
Cardiomyopathy,hypertrophic;
Dobutamine;
Echocardiography,stress
- From:
Chinese Journal of Cardiology
2008;36(5):412-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficiency of the dobutamine stress echocardiography in patients with hypertrophic cardiomyopathy and estimate the difference between provokable obstruction and resting obstruction in these patients.nethods Echocardiogarphy was performed in 22 patients with HCM(LVOTPG<50 mm Hg at rest, 1 mm Hg=0.133 kPa)at rest and at the end point of dobutamine stress.Dobutamine was administered via an infusion pump, starting at a dose of 5 μg·min-1·kg-1 and increasing every 5 minutes by 5μg·min-1·kg-1 till the maximum dose of 20μg·min-1·kg-1.Fifty-seven patients with HCM(LVOTPG>50 mm Hg at rest)were also studied at rest.Results In these 22 patients, the mean maximum velocity of LVOT was 5.39±1.60 m/s, the mean maximum LVOTPG was 125.7±62.4 mm Hg at the end point of dobutamine stress and the mean dose of dobutamine Was 13.90 ±6.85 μg·min-1·kg-1.Sixteen patients evidenced positive stress results at the end point of dobutamine stress.The main difference between the provokable obstruction and resting obstruction was that in provokable obstruction patients, the SAM positive patients were fewer and the proportion of Maron Ⅱ patients was higher(50%).Conclusions Dobutamine stress echocardiography Was a safe and sensitive way for detecting patients with hypertrophic cardiomyopathy.Provokable obstruction patients had fewer SAM and higher proportion of Maron Ⅱ.
