The relationship between the effect of amlodipine on carotid intimal-medial thickness and angiotensin converting enzyme genotypes in elderly hypertensive patients
10.3321/j.issn:0253-3758.2008.06.008
- VernacularTitle:氨氯地平逆转颈动脉内中膜增厚作用与血管紧张素转换酶基因型的相关性
- Author:
Li-Hua ZHAI
1
;
Sha-Yan WANG
;
Xu LIANG
;
Chun-Yu YANG
;
Ruan-Zhang ZHANG
;
Zeng-Ying WANG
;
Jun TANG
;
Yu-Hua HU
Author Information
1. 暨南大学附属第二医院(深圳市人民医院)
- Keywords:
Hypertension;
Peotidyl-dipoptidase A;
Genotype;
Calcium channl blockers;
Treatment outcome
- From:
Chinese Journal of Cardiology
2008;36(6):510-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the anti-atherosclerotic effects of amlodipine and angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in elderly essential hypertensive (EH) patients.Methods A total of 220 EH patients were treated with amlodipine (2.5-10 mg,once daily) for twelve months and complete data were obtained from 208 patients with genotypes of Ⅱ(n=90),ID (n=91) and DD (n=27).The indices ofcarotid arterial were compared before and post amlodipine treatment in patients with identical genotype and among different ACE genotypes and each genotype post therapy.Results The carotid mean intimal-medial thickness (MIMT) wag slightly decreased in EH patients with ID and DD genotypes and significantly decreased in EH patients with Ⅱgenotype (0.96 4±0.12 VS.0.92±0.13,P<0.01) compared to pre-treatment values.The decreased degree of MIMT (AMIMT) in Ⅱ genotype was significantly higher in Ⅱ genotype than those in ID or DD genotype (0.05±0.03 VS.0.01±0.02,0.01±0.03 respectively,P<0.01).The post treatment plaque score (PS) in patients with Ⅱ genotype was significantly reduced(4.85±2.51 vs.3.90 ± 2.36,P<0.05).Multivariate linear regression analysis showed the baseline SBP,the decreased degree of SBP (ASBP) and the Ⅱ genotype were the major factors affecting the △MIMT.Conclusion Hypertensive patients carrying Ⅱ genotype ACE genotype are the best responders for the anti-atherosclerotic effects of amlodiping.
