The relation between positive rate of autoantibodies against beta1 and M2-adrenergic receptors and urinary albumin excretion rate in the type 2 diabetes mellitus with refractory hypertension.
- Author:
Lin-shuang ZHAO
1
;
Yu-hua LIAO
;
Guang-da XIANG
;
Min WANG
;
Ling LE
;
Zi-hua ZHOU
;
Xuan LIN
;
Hui-ling SUN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Albuminuria; etiology; Autoantibodies; analysis; Diabetes Mellitus, Type 2; complications; immunology; Female; Humans; Hypertension; complications; immunology; Male; Middle Aged; Receptor, Muscarinic M2; immunology; Receptors, Adrenergic, beta-1; immunology
- From: Chinese Journal of Cardiology 2008;36(6):527-530
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relation between the positive rates of autoantibodies against beta(1) adrenergic receptor (beta1-receptor)and (M2-receptor) with urinary albumin excretion rate (UAER) in type 2 diabetes patients with refractory hypertension.
METHODSAutoantibodies against beta(1)- and M(2)-receptor as well as autoantibodies were determined in type 2 diabetes patients with (n = 136) or without (n = 111) refractory hypertension, hypertensive patients without renal failure (n = 60) and healthy control subjects (n = 40, control) by ELISA.
RESULTSThe positive rates of the autoantibodies against beta1-receptors (44.9%) and M(2)-receptor (37.5%) in patients with type 2 diabetes with refractory hypertension were significantly higher than those in patients with type 2 diabetes without refractory hypertension (27.9% and 24.3%, respectively, all P < 0.05), in patients with hypertension without renal failure (11.7% and 15.0%, all P < 0.01) and in healthy controls (8.3% and 7.5%, all P < 0.01). In type 2 diabetes patients with refractory hypertension and renal failure (UAER > or = 200 microg/min), the positive rates of the autoantibodies against beta(1)-receptor (87.1%, 27/31) and against M(2)-receptor (67.7%, 21/31) were significantly higher than those in type 2 diabetes patients with refractory hypertension but without renal failure (UAER 20 - 199 microg /min, 46.7%, 28/60 and 41.7%, 25/60, respectively, all P < 0.05).
CONCLUSIONThe serum beta(1)- and M (2)-receptor autoantibodies are positively associated with the UAER level and suggest that these autoantibodies against beta(1) and M(2)-receptor may play important roles in the pathogenesis of the type 2 diabetes with refractory hypertension.