The relation between positive rate of autoantibodies against β1 and M2-adrenergic receptors and urinary albumin excretion rate in the type 2 diabetes mellitus with refractory hypertension
10.3321/j.issn:0253-3758.2008.06.012
- VernacularTitle:2型糖尿病并难治性高血压抗β1肾上腺素能和M2胆碱能受体自身抗体与蛋白尿的关系
- Author:
Lin-Shuang ZHAO
1
;
Yu-Hua LIAO
;
Guang-Da XIANG
;
Min WANG
;
Ling LE
;
Zi-Hua ZHOU
;
Xuan LIN
;
Hui-Ling SUN
Author Information
1. 解放军广州军区武汉总医院
- Keywords:
Diabetes mellitus,type 2;
Hypertension;
Autoantibodies;
Albuminuria
- From:
Chinese Journal of Cardiology
2008;36(6):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation between the positive rates of autoantibodies against β1 adrenergic receptor(β1-receptor) and (M2-receptor) with urinary albumin excretion rate (UAER) in type 2 diabetes patients with refractory hypertension.Methods Autoantibodies against β1-and M2-receptor as well as autoantibodies were determined in type 2 diabetes patients with(n=136)or without(n=11 1) refractory hypertension,hypertensive patients without renal failure (n=60) and healthy contrel snbjects (n=40.control) by ELISA.Resuits The positive rates of the autoantibodies against β1.receptors (44.9%) and M2-receptor(37.5%)in patients with type 2 diabetes with refractory hypertension were significantly higher than those in patients with type 2 diabetes without refractory hypertension (27.9% and 24.3%,respectively.all P<0.05),in patients with hypertension without renal failure(11.7%and 15.0%.all P<0.01) and in healthy controls(8.3%and 7.5%,all P<0.01).In type 2 diabetes patients with refractory hypertension and renal failure (UAER≥200 μg/min),the positive rates of the autoantibodies against β1-receptor(87.1%,27/31)and against M2-receptor (67.7%,21/31) were significantly higher than those in type 2 diabetes patients with refractory hypertension but without renal failure (UAER 20-199 μg/min,46.7%,28/60 and 41.7%,25/60.respectively.all P<0.05).Conclusion The serum β1-and M2-receptor autoantibodies are positively associated with the UAER level and suggest that these autoantibodies against β1 and M2-receptor may play important roles in the pathogenesis of the type 2 diabetes with refractory hypertension.
