Ischemic myocardial viability assessment with interleaved T1-T2* magnetic resonauce imaging
10.3321/j.issn:0253-3758.2008.06.015
- VernacularTitle:交替进行纵向弛豫时间-横向弛豫时间磁共振成像判断缺血心肌活力的实验研究
- Author:
Gang LI
1
;
Wei-Chen TIAN
;
Ya-Nan JI
;
Song-Mei LI
;
Bo YU
;
Gang-Hong TIAN
Author Information
1. 哈尔滨医科大学附属第二医院
- Keywords:
Myocardial infarction;
Magnetic resonance imaging;
Myocardial viability;
Contrast agent;
Swine
- From:
Chinese Journal of Cardiology
2008;36(6):536-540
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of ischemic myocardial viability assessment using interleaved T1-T2*magnetic resonance imaging.Methods The left anterior descending coronary arteries (LAD)were occluded for 2 hours,followed by 1-hour reperfusion in 7 pigs.The hearts were then removed and perfused with a mixture of pig blood and crystalloid solution in 1:1 ratio.T1 relaxation times of the myocardium were measured with a TurboFLASH inversion。recovery sequence.The contrast agent,Gadolinium diethylenetriamine pentoacetie acid(Gd-DTPA)Was then inieeted as a bolus into the aortic perfusion line(0.05 mmol／kg body wt).The first pass of the contrast agent through the heart was followed using the interleaved T1-T2* imaging sequence.Once the concentration of Gd-DTPA was in an equilibrium state,T1 relaxation times were measured again.Results The percentage recovery of T2* intensity(PRT2*)at the maximum T1 intensity measured during the first pass of the contrast agent with the interleaved T1-T2*imaging was statistically different in normal myocardium(37±11)%,infarct rim(90±15)%and infarct core(100±5)%,F=66.585,P=0.000.Moreover,the infarcted regions shown on PRT2* maps matched well with the infarcted myocardium measured by TTC staining.The median of T1 relaxation time in normal region,infarct rim and infarct COre was 53l ms,541 ms and 1298 ms,respectively (H=6.284,P=0.043).However,normal region could not be differentiated from infarct rim with T1 relaxation times(q=0.082,P=0.775).Conclusion Infarcted myocardium and isehemic myocardial viability can be correctly identified and evaluated by the interleaved T1-T2* magnetic resonance imaging in this model.
