Relationship between cyclin G1 and human papilloma virus infection in cervical intraepithelial neoplasia and cervical carcinoma.
- Author:
Jing LIANG
1
;
Mei-Lu BIAN
;
Qing-Yun CHEN
;
Xia LIU
;
Hua OU
;
Min LI
;
Jun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; metabolism; virology; Case-Control Studies; Cervical Intraepithelial Neoplasia; metabolism; virology; Cyclin G; Cyclin G1; Cyclins; metabolism; Female; Human papillomavirus 16; genetics; isolation & purification; Human papillomavirus 18; genetics; isolation & purification; Humans; Immunohistochemistry; In Situ Hybridization; Papillomavirus Infections; metabolism; virology; Uterine Cervical Neoplasms; metabolism; virology
- From: Chinese Medical Sciences Journal 2006;21(2):81-85
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the overexpression of cyclin G1 in cervical intraepithelial neoplasia (CIN) and cervical carcinoma, and the correlation between cyclin G1 and high-risk human papilloma virus (HPV) infection.
METHODSAll of the specimens were obtained from the Department of Pathology of China-Japan Friendship Hospital from January 2000 to August 2004. We detected the expression of cyclin G1 with immunohistochemistry, HPV16/18 infection with in situ hybridization, and high-risk HPV infection with Hybrid capture system II (HC-II) in normal group (25 cases), CIN I (48 cases), CIN II (56 cases), CIN III (54 cases), and invasive cervical squamous-cell carcinoma (SCC, 31 cases).
RESULTSThe positive rates of cyclin G1 expression in CIN (77.85%) and SCC cervical tissues (87.10%) were significantly higher than normal (8.00%, P < 0.01), and the intensities of cyclin G1 expression in CIN (40.60%) and SCC cervical tissues (61.51%) were significantly higher than normal (2.72%, P < 0.05). The positive rates and intensities of cyclin G1 expression increased gradually with the grade of cervical lesions. High-risk HPV infection rates were higher in CIN and SCC than normal groups (P < 0.05). There was a positive correlation between cyclin G1 expression and high-risk HPV infection detected with HC-II (Kendall's tau-b = 0.316, 0.269, 0.352, and 0.474 in CIN I, CINII, CIN III, and SCC, respectively, P < 0.05).
CONCLUSIONSCyclin G1 is overexpressed in CIN and SCC. Cyclin G1 may be a biomarker for detecting CIN and SCC. Cyclin G1 may play an important role in the oncogenesis of CIN and SCC by high-risk HPV infection.