Effects of vitamin D receptor gene polymorphisms on susceptibility to type 1 diabetes mellitus.
- Author:
Xin-Hua XIAO
1
;
Zhe-Long LIU
;
Heng WANG
;
Qi SUN
;
Wen-Hui LI
;
Guo-Hua YANG
;
Qiu-Ying LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; Base Sequence; Case-Control Studies; Child; China; DNA Primers; genetics; Diabetes Mellitus, Type 1; genetics; Female; Gene Frequency; Humans; Male; Polymorphism, Restriction Fragment Length; Receptors, Calcitriol; genetics
- From: Chinese Medical Sciences Journal 2006;21(2):95-98
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the influence of vitamin D receptor (VDR) gene polymorphisms on susceptibility to type 1 diabetes mellitus (T1DM) in the Chinese Han population.
METHODOne hundred and thirty-six Chinese Han people, including 54 T1DM patients and 82 unrelated healthy subjects as control were genotyped by polymerase chain reaction-restriction fragment length polymorphism for three restriction sites in the VDR gene, which were ApaI, TaqI, and BamI.
RESULTSThe frequency of B allele of BsmI site in VDR gene was significantly higher in T1DM patients than in healthy subjects (P = 0.033) while no difference was found between the two groups in the distribution of ApaI and TaqI polymorphisms.
CONCLUSIONThe BsmI polymorphism of VDR gene may be associated with the susceptibility to T1DM in the Chinese Han population of Beijing.
