The protective effect of Yuyin Ruangan Decoction on experimental hepatic injury.
- Author:
Zhi-wang WANG
;
Xue-feng LU
;
Hai-yan TUO
;
Xiao-li CHENG
;
Mei GUO
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Antioxidants; metabolism; Aspartate Aminotransferases; blood; Chemical and Drug Induced Liver Injury; drug therapy; Drugs, Chinese Herbal; pharmacology; Glutathione Peroxidase; metabolism; Liver; drug effects; enzymology; Malondialdehyde; metabolism; Mice; Superoxide Dismutase; metabolism
- From: Chinese Journal of Applied Physiology 2015;31(1):76-79
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effects of Yuyin Ruangan Decoction(YRD, traditional Chinese medicine) on experimental hepatic injury in mice.
METHODSThe mice were randomly divided into control group, model group and YRD low, middle and high dose group(n = 11). By ip injection of D-GalN, CCk or thioacetamide (TAA), three models of hepatic injury mice were established to investigate the effects of YRD through detecting the indexes of liver function in serum and, the content of antioxidant system in the hepatic tissue.
RESULTSYRD could decrease the content of alanine aminotransferase (ALT)and aspartate aminotransferase (AST) in serum and that of malonaldehyde (MDA) in the hepatic tissue, upregulate the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hepatic tissue. Furthermore, the above effects were dosedependent in a certain degree. CoNCLUSION: YRD has some protection effects on the model of experimental hepatic injury in mouse.