Effect of Volatile Oil of Radix Angelicae Sinensis on experimental asthma in rats.
- Author:
Zhi-wang WANG
;
Rong-ke LI
;
Xing-yao LIN
;
Yuan REN
;
Xue-feng LIU
;
Xiao-li CHENG
;
Rui-qiong WANG
- Publication Type:Journal Article
- MeSH: Angelica sinensis; chemistry; Animals; Asthma; drug therapy; Bronchoalveolar Lavage Fluid; chemistry; Disease Models, Animal; Forkhead Transcription Factors; metabolism; Interleukin-10; chemistry; Lung; metabolism; Oils, Volatile; pharmacology; Plant Oils; pharmacology; Rats; T-Lymphocytes, Regulatory; cytology
- From: Chinese Journal of Applied Physiology 2015;31(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Volatile Oil of Radix Angelicae Sinensis (VOA) on experimental asthma in rat model based on abnormal immune functions of Treg cells.
METHODSAfter grouping, the asthmatic rats were developed through injecting OVA and AI(OH)3 for sensitization and then administering OVA aerosol for challenge, and the respiratory functions, asthmatic behaviors, IL-10 levels in bronchoalveolar lavage fluid (BALF) (ELISA) and Foxp3 expression (immunohistochemistry) in lung of asthmatic rats were observed.
RESULTSVOA at the doses of 40-160 mg/kg could improve the respiratory functions and the asthmatic behaviors, and upgrade IL-10 levels in BALF and Foxp3 expression in lung of asthmatic rats.
CONCLUSIONVOA has some effects of anti-asthma and one of the mechanisms is to improving the lower immune functions of Treg cells.