A case of myelodysplastic syndrome with aberrant evolution of chromosome 1 and 11 in 6 years of follow-up.
- Author:
Xin LÜ
1
;
Hong-Xia QIU
;
Hai-Rong QIU
;
Su-Jiang ZHANG
;
Ji XU
;
Wei XU
;
Han-Xin WU
;
Jian-Yong LI
;
Jing-Zhang SHAO
Author Information
1. Department of Hematology, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
- Publication Type:Case Reports
- MeSH:
Adult;
Chromosome Aberrations;
Chromosomes, Human, Pair 1;
Chromosomes, Human, Pair 11;
Follow-Up Studies;
Humans;
Karyotyping;
Male;
Middle Aged;
Myelodysplastic Syndromes;
genetics
- From:
Journal of Experimental Hematology
2010;18(2):469-472
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the relationship between cytogenetic evolution and disease progression in patient with MDS-RAEB. By a long term (6 years) follow-up of a patient with MDS-RAEB, peripheral blood cell count, bone marrow cell morphology and conventional cytogenetics were monitored regularly. In addition, fluorescence in situ hybridization (FISH) was applied to confirm the aberrant karyotype. The results indicated that this patient was failed with conventional chemotherapy of AML, but had response to ATRA and 6-MP in the 72 months follow-up. At initial diagnosis, the cytogenetics analysis showed normal karyotype, whereas 46, XY, 2q+[1]/46, XY[19] was found at 48 months, 46, XY, dup(1q)[3]/46, XY[7] at 56 months, and dup (1) as well as der (11) with complex karyotype at 68 months, which was accompanied by progressive decrease of platelet count. It is concluded that karyotype evolution is perhaps associated with progression of MDS.
