Frequencies of high-resolution HLA-Cw* alleles in China Northern Han population.
- Author:
Xiao-Lan LIANG
1
;
Jun-Ling HAN
;
Qian LI
;
Le-Jing SUN
;
Ying DU
;
Lan-Ting LIU
;
Lu-Gui QIU
Author Information
1. Union Stem Cell & Gene Engineering Co., Ltd., Tianjin Cord Blood Bank, Tianjin 300384, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Alleles;
Asian Continental Ancestry Group;
genetics;
Child;
Child, Preschool;
China;
Female;
Gene Frequency;
Genotype;
HLA-A Antigens;
genetics;
HLA-B Antigens;
genetics;
HLA-C Antigens;
genetics;
Haplotypes;
Humans;
Infant;
Male;
Middle Aged;
Polymorphism, Genetic;
Young Adult
- From:
Journal of Experimental Hematology
2010;18(2):486-489
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the frequencies of HLA-Cw* loci in China Northern Han population at gene level and to analyze the population genetic characteristics of HLA-Cw* alleles and distribution difference of gene frequency in regions. The high resolution genotyping for HLA-Cw* loci of 420 cases in China Northern Han population was performed by using PCR-SSP typing technique and their distribution regularity was analyzed statistically. The results showed that 30 HLA-Cw* alleles were detected, among which the frequency of Cw* 0102 (0.1776), 0702 (0.1217), 0602 (0.1150) were highest; other alleles with higher frequency were as follow in proper order: Cw* 0304, 0801, 0303, 0302, 0401, 1402. The rare observed HLA-Cw* 0506, 0810, 1510, 1601 and 1701 were detected firstly in this population. The statistical analysis indicated that the genotype distribution of HLA-Cw* loci coincides with the Hardy-Weinberg test. In conclusion, application of high resolution allele typing can accurately understand the distribution regularity and characteristics of HLA-Cw* alleles in China Northern Han population which provides the basis for research related with HLA-Cw* loci.
