Epigenetic mechanism of RUNX1 in pathogenesis of leukemia.
- Author:
Han ZHANG
1
;
Hu-Yong ZHENG
Author Information
1. Hematological Center, Beijing Children Hospital, Capital Medical University, Beijing 100045, China.
- Publication Type:Journal Article
- MeSH:
Core Binding Factor Alpha 2 Subunit;
genetics;
Epigenesis, Genetic;
Humans;
Leukemia;
genetics;
metabolism;
Protein Processing, Post-Translational
- From:
Journal of Experimental Hematology
2010;18(2):525-530
- CountryChina
- Language:Chinese
-
Abstract:
RUNX1, also called AML1, is a member of RUNX transcriptional factor family, and also is the most frequent target for chromosomal translocations in leukemia. RUNX1 is a very important transcription factor, can enhance or repress the expressions of many hematopoiesis related genes. RUNX1 may receive a series of post-translational modifications, and the activity of RUNX1 can be affected by these post-translational modifications, thus RUNX1 regulates the differentiation, apoptosis and self-renewal of hematopoietic cells. This article reviews the role of RUNX1 in the pathogenesis of leukemia mainly including its target genes, transcriptional mechanism and post-translational modifications.
