Effect of nerve growth factor on adhesion and motional abilities of tumor cells and their correlation
10.3760/cma.j.issn.1002-0098.2010.09.005
- VernacularTitle:腺样囊性癌嗜神经侵袭中神经生长因子、上皮钙黏素和钙结合蛋白A4的表达及意义
- Author:
Shu-Yu LUO
1
;
Jian-Ming ZHANG
;
Hong-Jie LI
;
Shan-Chuan ZHENG
;
Yu-Ru ZHANG
;
Xiao-Hong ZHU
Author Information
1. 天津医科大学口腔医院
- Keywords:
Nerve growth factor;
Cadherins;
Carcinoma,adenoid cystic;
Perineural invasion
- From:
Chinese Journal of Stomatology
2010;45(9):531-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect on adhesion and motion capbilities of adenoid cystic carcinoma(ACC) , by detecting the expression of nerve growth factor (NGF) , E-cadherin (E-cad) and S100A4 and the clinical significance in ACC tissues and analyzing the relationships between them with perineural invasion(PNI). Methods The expression of NGF, E-cad and S100A4 in ACC was detected with the way of immunohistochemistry SP, and then analyzing the expression level of them in different pathological types and histological regions in statistical ways on the basis of their relation with clinical and pathological parameters. Results The expression of NGF and S100A4 in PNI group [ 88% (23/26) and 77% (20/26) ] , was higher than that in NPNI group (8/16 and 7/16, P <0.05), and a positive correlation between them was identified in PNI group(r =0. 316,P <0.05). However the E-cad expression was lower in PNI group[31%(8/26) ,P<0. 05]. On the other hand it suggested a negative correlation with NGF (r = 0.385, P<0.05) as well as that with S100A4(r = -0.612,P =0.000). The expression level of NGF in fasciculus[ 83% (25/30)] has significant deviation compared with it in distant tumor tissues [ 47% (14/30), P<0. 05]. Conclusions In the PNI process of ACC, NGF plays important parts but not the only factor. It can increase the expression and activity of S100A4 but decrease E-cad expression through binding with its receptor. Thus, adhesion abilities of tumor cells was weakened and motional abilities was strengthen.
