Effects of clotrimazole on the growth of oral squamous cell carcinoma.
- Author:
Hui LIU
1
;
Yue-Hong WANG
;
Zhan-Gui TANG
;
Ou-Sheng LIU
;
Jie ZHANG
;
Gui-Yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; pathology; Cell Cycle; Cell Cycle Checkpoints; Cell Division; Cell Line, Tumor; Clotrimazole; pharmacology; Cyclin E; Humans; Mouth Neoplasms; pathology; Oncogene Proteins
- From: Chinese Journal of Stomatology 2010;45(9):545-548
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEto investigate the effects of clotrimazole on the growth of oral squamous cell carcinoma (OSCC).
METHODSOSCC-25 cells growing in log phase were treated with various doses of clotrimazole. The concentration of IC(50), cell cycle and cell cycle related protein were examined.
RESULTSthe concentration of clotrimazole for inhibiting OSCC was IC(50) 8.51 µmol/L. Clotrimazole induced cell cycle arrest in the G(0)-G(1) cell cycle phase, with a concomitant decrease of cells in the G(2)-M and S-phase. Furthermore, clotrimazole significantly decreased the levels of cyclin D, cyclin E and CDK-4.
CONCLUSIONSclotrimazole inhibits the growth of OSCC.
