Acute Hemolysis and Renal Failure caused by Hepatitis A Infection with Underlying Glucose-6-Phosphate Dehydrogenase Deficiency.
10.3343/kjlm.2007.27.3.188
- Author:
Dong Wook JEKARL
1
;
Eun Jee OH
;
Yeon Joon PARK
;
Kyung Ja HAN
;
Sung Won LEE
;
Chong Won PARK
Author Information
1. Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. ejoh@catholic.ac.kr
- Publication Type:Case Report ; Case Reports ; English Abstract
- Keywords:
Glucose-6-phosphate dehydrogenase deficiency;
Hepatitis A virus;
Hemolytic anemia;
Acute renal failure
- MeSH:
Adult;
Diagnosis, Differential;
Glucosephosphate Dehydrogenase/genetics;
Glucosephosphate Dehydrogenase Deficiency/*complications/diagnosis;
*Hemolysis;
Hepatitis A/*complications/diagnosis;
Hepatitis A Virus, Human/isolation & purification;
Humans;
Hyperbilirubinemia/etiology;
Kidney Failure, Acute/*diagnosis/etiology;
Male
- From:The Korean Journal of Laboratory Medicine
2007;27(3):188-191
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder worldwide, it has rarely been reported among Korean. The patient was previously healthy 39 yr old male who showed severe hemolytic anemia and acute renal failure accompanied by hyperbilirubinemia after hepatitis A infection. The additional studies for differential diagnosis of hemolytic anemia showed a moderate deficiency of G6PD enzyme. Because hepatitis A infection in patient with G6PD deficiency present much more severe clinical symptoms, G6PD enzyme should be examined in patients with triggering factors of hemolysis such as hepatitis A infection.
