Effects of C-reactive protein on chemotaxis ability of monocytes in vitro.
- Author:
Shu MENG
1
;
Lin ZHANG
;
He YANG
;
Ya-fei WU
;
Song GE
;
Lei ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: C-Reactive Protein; Chemokine CCL2; Chemotaxis; Humans; In Vitro Techniques; Monocytes
- From: West China Journal of Stomatology 2009;27(6):673-675
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of C-reactive protein (CRP) on monocytes chemotaxis ability in vitro.
METHODSTranswell chemotaxis assay was used to evaluate the changes of chemotactic ability of THP-1 monocytes in each group treated with CRP in different concentration.
RESULTSCRP increased the number of attracted monocytes in response to MCP-1 (monocyte chemoattractant protein-1). When treated with CRP concentration at 2 microg x mL(-1), the number of chemotactic monocytes increased (P < 0.05). The number of attracted monocytes increased as CRP concentration was elevated (P < 0.05).
CONCLUSIONCRP can increase chemotactic ability of THP-1 monocytes in concentration dependent manner.
