The Analysis of Bone regenerative effect with carriers of bone morphogenetic protein in rat calvarial defects.
10.5051/jkape.2007.37.4.733
- Author:
Sung Won JUNG
1
;
Jee Hee JUNG
;
Gyung Joon CHAE
;
Ui Won JUNG
;
Chang Sung KIM
;
Kyoo Sung CHO
;
Jung Kiu CHAI
;
Chong Kwan KIM
;
Seong Ho CHOI
Author Information
1. Department of periodontology, Research institute for periodontal Regeneration, College of Dentistry, Yonsei University, Korea. shchoi726@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Bone morphogenetic protein;
carrier;
rat calvarial defect model
- MeSH:
Animals;
Bone Density;
Bone Morphogenetic Proteins*;
Bone Regeneration;
Rats*;
Tissue Engineering
- From:The Journal of the Korean Academy of Periodontology
2007;37(4):733-742
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bone morphogenetic proteins have been shown to possess significant osteoinSductive potential, but in order to take advantage of this effect for tissue engineering, carrier systems are essential. Successful carrier systems must enable vascular and cellular invasion, allowing BMP to act as a differentiation factor. The carrier should be reproducible, non-immunogenic, moldable, and space-providing, to define the contours of the resulting bone. The purpose of this study was to review available literature, in comparing various carriers of BMP on rat calvarial defect model. The following conclusions were deduced. 1. Bone regeneration of ACS/BMP, beta-TCP/BMP, FFSS/BMP, FFSS/beta-TCP/BMP, MBCP/BMP group were significantly greater than the control groups. 2. Bone density in the ACS/BMP group was greater than that in beta-TCP, FFSS, FFSS/beta-TCP carrier group. 3. Bone regeneration in FFSS/BMP group was less than in ACS/BMP, beta-TCP/BMP, MBCP/BMP group. However, New bone area of FFSS/beta-TCP/BMP carrier group were more greater than that of FFSS/BMP group. ACS, beta-TCP, FFSS, FFSS/beta-TCP, MBCP were used for carrier of BMP. However, an ideal carrier which was reproducible, non-immunogenic, moldable, and space-providing did not exist. Therefore, further investigation are required in developing a new carrier system.
