The relationship between CD4+ CD25+ regulatory T cell in the peripheral blood and poor or nonresponsiveness to hepatitis B vaccine.
- Author:
Wei NIU
1
;
Zhao YANG
;
Xiao-yun SHANG
;
Xiao-lan FU
;
Yan TANG
;
Man JIANG
;
Li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Blood; immunology; CD4 Antigens; immunology; Female; Flow Cytometry; Hepatitis B Vaccines; immunology; Humans; Interleukin-2 Receptor alpha Subunit; immunology; Male; Middle Aged; T-Lymphocyte Subsets; immunology; T-Lymphocytes, Regulatory; immunology; metabolism; Young Adult
- From: Chinese Journal of Preventive Medicine 2009;43(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate CD4+ CD25+ regulatory T cell frequencies in the peripheral blood of poor or non-responsiveness to Hepatitis B vaccine, and try to understand the relationship between CD4+ CD25+ regulatory T cell and poor or non-responsiveness to Hepatitis B vaccine.
METHODSFlow cytometric analysis was employed for CD4+ CD25+ regulatory T cell frequencies in the peripheral blood of 25 cases of non-responsiveness, 30 cases of poor-responsiveness, and collected 20 cases of responsiveness as control.
RESULTSCD4+ CD25+ regulatory T cell frequencies of responsiveness was (4.32 +/- 1.21)%, poor-responsiveness was (7.01 +/- 1.06)% and non-responsiveness was (12.75 +/- 2.01)%. It was found that non and poor-responsiveness showed a high percentage of CD4+ CD25+ regulatory T cell as compared with responsiveness (t = 8.426, t = 3.289, P<0.01).
CONCLUSIONThe poor and non-responsiveness should be related with the increase of CD4+ CD25+ regulatory T cell and this might be considered as an important cause of poor and non-responsiveness.
