Transfusion of activated immune cells induced fluctuations of HCV titer without mutations in hepatitis C virus core and E2 region CTL epitopes.
- Author:
Qixin WANG
1
;
Hongsong CHEN
;
Xu CONG
;
Ran FEI
;
Yan GAO
;
Jing SUN
;
Lai WEI
;
Yu WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alanine Transaminase; blood; Epitopes; genetics; Female; Genetic Variation; Hepacivirus; genetics; Hepatitis C, Chronic; blood; therapy; virology; Humans; Immunotherapy; Male; Middle Aged; Viral Core Proteins; genetics; Viral Envelope Proteins; genetics; Viral Load
- From: Chinese Journal of Experimental and Clinical Virology 2002;16(4):329-332
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the variations of HCV core and E2 region epitopes during transfusion of activated immune cells.
METHODSFour patients receiving transfusion of activated immune cells were under continuously observation. HCV titers were measured by quantitive PCR. HCV core and E2 regions were cloned and sequences were analyzed by computer software.
RESULTSDuring the follow-up the serum ALT levels and the HCV virus titers fluctuated greatly in each of these persons. After transfusion, no significant variations were observed in HCV core and E2 coding regions.
CONCLUSIONSThe alteration of host immune attacks could induce the fluctuations of HCV load without any mutations in the currently observed coding genes of the epitopes.
