Advances in microbial production of 5-aminolevulinic acid.
- Author:
Zhen KANG
1
;
Junli ZHANG
1
;
Sen YANG
1
;
Guocheng DU
2
;
Jian CHEN
2
Author Information
1. Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
2. School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.
- Publication Type:Journal Article
- MeSH:
Aminolevulinic Acid;
metabolism;
Escherichia coli;
genetics;
metabolism;
Metabolic Engineering;
Mutation;
Rhodobacter sphaeroides;
genetics;
metabolism
- From:
Chinese Journal of Biotechnology
2013;29(9):1214-1222
- CountryChina
- Language:Chinese
-
Abstract:
5-Aminolevulinic acid is the key intermediate of the tetrapyrrole biosynthesis pathway in organisms and has broad application potentials. This review summarized and discussed recent progress in microbial production of 5-aminolevulinic acid, including screening, isolation and mutation of microbes to produce 5-aminolevulinic acid; microbial whole-cell transformation to synthesize 5-aminolevulinic acid depending on the C4 pathway; construction of high-yield 5-aminolevulinic acid producing strains by metabolic engineering. Finally, future research directions in microbial production of 5-aminolevulinic acid were addressed.
