Advances of consolidated bioprocessing based on recombinant strategy.
- Author:
Zongbao ZHENG
1
;
Meina ZHAO
1
;
Tao CHEN
1
;
Xueming ZHAO
1
Author Information
1. Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
- Publication Type:Journal Article
- MeSH:
Bacteria;
genetics;
metabolism;
Biofuels;
Biotechnology;
methods;
Ethanol;
metabolism;
Fungi;
genetics;
metabolism;
Hydrolases;
biosynthesis;
genetics;
Industrial Microbiology;
methods;
Lignin;
metabolism;
Metabolic Engineering;
methods;
Recombinant Proteins;
biosynthesis;
genetics
- From:
Chinese Journal of Biotechnology
2013;29(10):1354-1362
- CountryChina
- Language:Chinese
-
Abstract:
Lignocellulosic biomass represents an abundant, low-cost and renewable source of potentially fermentable sugars. It is acandidate besides petroleum as feedstock for fuel and chemical production. Recent researches on utilizing lignocellulosicsas feedstock boost development of numerous-promising processes for a variety of fuels and chemicals, such as biodiesel, biohydrogen and ethanol. However, high cost in depolymerization is a primary obstacle preventing the use of lignocellulosic biomass as feedstock. Consolidated bioprocessing (CBP), refers to the bioprocess without any exogenous cellulolyotic enzymes added, converting the lignocellulosic material into biochemicals directly, which could potentially avoid the cost of the dedicated enzyme generation step by incorporating enzyme-generating, biomass-degrading and bioproduct-producing capabilities into a single organism through genetic engineering. There are two CBP strategies, native strategy and recombinant strategy. We mainly introduce the recombinant strategy, including its principle, the two responding styles, the contributions of synthetic biology and metabolic engineering and the future challenges.
