Essential role of mitochondria in tumorigenesis.
- Author:
Chunling TANG
;
Zhonghuai XIANG
;
Hongjuan CUI
- Publication Type:Journal Article
- MeSH:
Animals;
Energy Metabolism;
Humans;
Mitochondria;
metabolism;
physiology;
Neoplasms;
etiology;
genetics;
physiopathology;
Tumor Microenvironment;
physiology
- From:
Chinese Journal of Biotechnology
2013;29(11):1548-1557
- CountryChina
- Language:Chinese
-
Abstract:
Tumorigenesis is a complex process that is regulated by a variety of network signals. With the continuous development of the process, tumor cells gradually exhibit lots of hallmarks.Tumor cells have the characteristics of unlimited proliferation, resistance to apoptosis, evading immune surveillance, among others. As a unique organelles, mitochondria play an important role in cellular energy metabolism, reactive oxygen species producing and apoptosis process. Particularly, mitochondria have a close relationship with tumor development. In this review, we focus on the essential role of mitochondria in tumor cells development.
