Pathological basis of qi-deficiency and blood stasis syndrome in patients with non-small cell lung cancer viewing from tumor metastasis related factors.
- Author:
Xiao-Qin LUO
1
;
Yong-Mei XU
;
Yong TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Non-Small-Cell Lung; diagnosis; pathology; Diagnosis, Differential; Endostatins; blood; Female; Humans; Hyaluronan Receptors; blood; Intercellular Adhesion Molecule-1; blood; Lung Neoplasms; diagnosis; pathology; Male; Medicine, Chinese Traditional; methods; Middle Aged; Neoplasm Metastasis; diagnosis; pathology; Vascular Endothelial Growth Factor A; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2009;29(10):886-888
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the expressions of tumor metastasis related factors (TMRF) in peripheral blood of patients with non-small cell lung cancer (NSCLC) for exploring the molecular mechanism for genesis of qi-deficiency and blood stasis (QDBS) syndrome in patients.
METHODSEighty selected NSCLC patients of stage II B/III were differentiated into the QDBS group and the non-QDBS group according to the Chinese medicine syndrome differentiation criteria, 40 in each group. The serum levels of vascular endothelial growth factor (VEGF), endostatin (ES) and soluble intercellular adhesive molecule-1 (slCAM-1) in patients were detected by ELISA, and the expression of adhesive molecule CD44 in peripheral blood was determined using flow cytometry.
RESULTSSerum levels of VEGF (1002.78 +/- 312.08 ng/L), ES (120.88 +/- 20.00 microg/L), slCAM-1 (531.78 +/- 213.37 microg/L) and CD44 (136.65 +/- 29.60) were significantly higher in patients of QDBS group than in patients of non-QDBS group (653.18 +/- 318.99 ng/L, 98.29 +/- 23.92 microg/L, 409.36 +/- 167.65 microg/L and 98.46 +/- 20.64, respectively, P<0.01).
CONCLUSIONObjective inner links are found between the QDBS syndrome and TMRF in NSCLC patients; serum levels of VEGF, ES, slCAM-1 and CD44 can be served as the microcosmic basis for QDBS syndrome differentiation.
