A multi-center randomized controlled trial on treatment of diarrhea-predominant irritable bowel syndrome by Chinese medicine syndrome-differentiation therapy.
- Author:
Sheng-sheng ZHANG
1
;
Hong-bing WANG
;
Zhen-hua LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Diarrhea; drug therapy; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Irritable Bowel Syndrome; drug therapy; Male; Middle Aged; Phytotherapy; Single-Blind Method; Treatment Outcome; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2010;30(1):9-12
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo verify the clinical efficacy of Chinese Medicine syndrome-differentiation therapy in treating diarrhea-predominant irritable bowel syndrome IBS-D.
METHODSWith a blinded randomized controlled design adopted, 360 patients with IBS-D were randomly assigned to two groups, the treated group and the control group, they were treated with Chinese medicine and Pinaverium bromide for four weeks respectively.
RESULTSComprehensive evaluation showed that the total effective rate in the treated group was higher than that in the control group significantly (93.8% vs 81.3%, P<0.01). Efficacy assessment on symptoms (by scoring) showed that the efficacy in the treated group was better than that in the control group in aspects of improving abdominal pain (86.1% vs 70.3%), defecation coziness (involving the frequency of defecation, incidence of tenesmus in the latest 10 days and Bristol typing of stool characters), living interfering, and total BSS score (P<0.05 or P<0.01).
CONCLUSIONChinese medicine syndrome-differentiation dependent therapy shows good efficacy in treating IBS-D.
