Progress in omics research of Aspergillus niger.

Yufei Sui; Liming Ouyang; Hongzhong LU; Yingping Zhuang; Siliang Zhang

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Progress in omics research of Aspergillus niger.

Author: Yufei SUI ¹ ; Liming OUYANG ¹ ; Hongzhong LU ¹ ; Yingping ZHUANG ¹ ; Siliang ZHANG ¹
Author Information

1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Publication Type:Journal Article
Keywords: Aspergillus niger; genome; genome-scale metabolic network model; metabolome; omics integration; proteome; transcriptome
MeSH: Aspergillus niger; genetics; Fermentation; Genome, Fungal; Metabolic Networks and Pathways; Metabolome; Proteome; Transcriptome
From: Chinese Journal of Biotechnology 2016;32(8):1010-1025
CountryChina
Language:Chinese
Abstract: Aspergillus niger, as an important industrial fermentation strain, is widely applied in the production of organic acids and industrial enzymes. With the development of diverse omics technologies, the data of genome, transcriptome, proteome and metabolome of A. niger are increasing continuously, which declared the coming era of big data for the research in fermentation process of A. niger. The data analysis from single omics and the comparison of multi-omics, to the integrations of multi-omics based on the genome-scale metabolic network model largely extends the intensive and systematic understanding of the efficient production mechanism of A. niger. It also provides possibilities for the reasonable global optimization of strain performance by genetic modification and process regulation. We reviewed and summarized progress in omics research of A. niger, and proposed the development direction of omics research on this cell factory.