Advances in metabolic engineering of Escherichia coli for isoprene biosynthesis.

Author: Jing GUO ¹ ; Yujin CAO ¹ ; Mo XIAN ¹ ; Huizhou LIU ¹
Author Information

1. CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China.
Publication Type:Journal Article
Keywords: Escherichia coli; isoprene; metabolic engineering; synthetic rubber
MeSH: Butadienes; Escherichia coli; Hemiterpenes; biosynthesis; Industrial Microbiology; Metabolic Engineering; Metabolic Networks and Pathways; Pentanes
From: Chinese Journal of Biotechnology 2016;32(8):1026-1037
CountryChina
Language:Chinese
Abstract: As an important industrial chemical, isoprene is mainly used as a precursor for synthetic rubbers. In addition, it also has wide applications in the field of pharmaceutical and chemical intermediates, food, adhesives and aviation fuel. Compared with conventional petrochemical routes, production of isoprene in microbial systems has been the research focus considering environment friendly and sustainable development features. This article summarizes the metabolic pathways and key enzymes of isoprene biosynthesis, reviews current methods and strategies in improving isoprene production of Escherichia coli, and also gives some basic ideas and expectation.