Strategies for producing high-yield viral vaccine antigens.

Author: Libao XIE ¹ ; Yongfeng LI ¹ ; Lingkai ZHANG ¹ ; Huaji QIU ¹
Author Information

1. Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, Heilongjiang, China.
Publication Type:Journal Article
Keywords: high-yield virus strain; vaccine production; viral vaccine antigen
From: Chinese Journal of Biotechnology 2017;33(8):1213-1223
CountryChina
Language:Chinese
Abstract: Vaccination is an important strategy to prevent infectious diseases. However, low antigen yield of vaccine producing strains may lead to high cost of vaccines, low antigen production and vaccine failure. In recent years, many efforts have been made to improve the antigen yield of many vaccines. This mini-review summarizes various methods for increasing the antigen yield for vaccine production, including genetic modification of viruses, improvement of the adaptation of viruses to cells, and optimization of antigen expression systems and manufacturing procedures. Furthermore, we discuss the advantages and the problems of current strategies, as well as indicate the perspectives.