Advances in mass spectrometry-based approaches for neuropeptide analysis.

Author: Qianyue JI ¹ ; Min MA ¹ ; Xin PENG ¹ ; Chenxi JIA ² ; Qianyue JI ¹
Author Information

1. School of Life Sciences, Tianjin University, Tianjin 300072, China.
2. Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing, Beijing 102206, China.
Publication Type:Journal Article
Keywords: identification; mass spectrometry; mass spectrometry imaging; neuropeptides; quantitation
From: Chinese Journal of Biotechnology 2017;33(7):1061-1068
CountryChina
Language:Chinese
Abstract: Neuropeptides are an important class of endogenous bioactive substances involved in the function of the nervous system, and connect the brain and other neural and peripheral organs. Mass spectrometry-based neuropeptidomics are designed to study neuropeptides in a large-scale manner and obtain important molecular information to further understand the mechanism of nervous system regulation and the pathogenesis of neurological diseases. This review summarizes the basic strategies for the study of neuropeptides using mass spectrometry, including sample preparation and processing, qualitative and quantitative methods, and mass spectrometry imagining.