Research progress in rotavirus VP4 subunit vaccine.

Author: Lianzhi JIA ¹ ; Tingdong LI ¹ ; Shengxiang GE ¹
Author Information

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infection Disease, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China.
Publication Type:Journal Article
Keywords: VP4; diarrhea; rotavirus; subunit vaccines
From: Chinese Journal of Biotechnology 2017;33(7):1075-1084
CountryChina
Language:Chinese
Abstract: Rotaviruses are leading causes of worldwide acute diarrhea in children younger than 5 years old, with severe consequence of social and economic burden. Vaccination is the most effective way to control rotavirus infection, however, the licensed rotavirus vaccines are ineffective in some low-income countries of Africa and Asia, where the mortality caused by rotavirus is higher than other areas. In addition, there are also safety concerns such as increased risk of intussusception. Therefore, it is urgent to improve the efficiency and safety of rotavirus vaccine to reduce the morbidity and mortality caused by rotavirus. Till now, many efforts are made to improve the effectiveness of rotavirus vaccines, and the inactive vaccine becomes the main trend in the research of rotavirus vaccine. The developments in recombinant rotavirus vaccines, especially in VP4 subunit vaccines are summarized in this review, and it could be helpful to develop effective recombinant rotavirus vaccines in further studies.