Application of nanobody in cancer treatment.

Author: Yue WU ¹ ; Xiujing HAO ¹ ; Min LI ¹
Author Information

1. Key Laboratory for Conservation and Utilization of Special Biological Resources in the Western China, Ministry of Education, Ningxia University, Yinchuan 750021, Ningxia, China.
Publication Type:Journal Article
Keywords: heavy-chain-only antibodies; nanobodies; oncology
From: Chinese Journal of Biotechnology 2017;33(7):1085-1090
CountryChina
Language:Chinese
Abstract: Camelidae can produce a unique antibody that lacks light chain called variable heavy chain domain, also known as nanobodies. This antibody contains only one variable region, with high affinity, high stability, strong tissue penetration, efficient expression. Besides, their toxicity and immunogenicity are both low to be used for both therapeutic and diagnostic applications, as well as research tools. In this review, we discuss how nanobody has been explored as therapeutics in oncology, and provide ideas for the further development of nanobody.