Study on expression of Ki-67, early apoptotic protein M30 in endometrial carcinoma and their correlation with prognosis.
- Author:
Yu-xin WU
1
;
Jing-hua WANG
;
Hua WANG
;
Xin-yun YANG
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; Endometrial Neoplasms; chemistry; mortality; pathology; Female; Humans; Immunohistochemistry; Keratins; analysis; Ki-67 Antigen; analysis; Neoplasm Staging; Prognosis
- From: Chinese Journal of Pathology 2003;32(4):314-318
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the correlation between expression of proliferation antigen Ki-67, early apoptotic protein M30 (M30CytoDEATH, CK18) and biologic characteristics in endometrial carcinoma.
METHODSSP immunohistochemical technique was used to detect the expression of Ki-67 and M30 in 79 cases of endometrial carcinoma respectively.
RESULTSThe mean Ki-67 indices varied with histological grading and clinical stage of the tumor, being 20.48 +/- 14.86 in grade 1, 24.12 +/- 14.42 in grade 2 and 38.84 +/- 11.88 in grade 3; 20.65 +/- 13.56 in stage I; 26.92 +/- 14.71 in stage II; and: 35.14 +/- 14.70 in stage III. The mean M30 indices varied with the grading and stage of the tumor, being 1.03 +/- 1.42 in grade 1, 1.03 +/- 1.64 in grade 2 and 1.94 +/- 1.20 in grade 3; 0.30 +/- 0.58 in stage I; 1.66 +/- 1.74 in stage II; and 2.07 +/- 1.62 in stage III.
CONCLUSIONSKi-67 and M30 indexes are significantly correlated with biologic behavior and prognosis in endometrial carcinoma. There is a positive relationship between Ki-67 and M30 indexes.
