Chronic lymphocytic leukemia with central nervous system invasion: one case report and literature review.
- Author:
Jianfeng ZHU
1
;
Zhengdong WU
1
;
Lei FAN
1
;
Wei XU
1
;
Jianyong LI
1
Author Information
- Publication Type:Case Reports
- MeSH: Aged; Central Nervous System; pathology; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; pathology; Leukemic Infiltration; Male; Prognosis
- From: Chinese Journal of Hematology 2014;35(7):592-595
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate clinical features, diagnosis, therapy, and prognosis in a case of chronic lymphocytic leukemia (CLL) with central nervous system (CNS) invasion.
METHODSThe cellular morphology of bone marrow, cytology and flow cytometry of cells in CSF, and radiographic manifestations were detected in a patient diagnosed as CLL with CNS invasion. The clinical features, pathogenesis, diagnosis,therapy, and prognosis of CLL with CNS invasion were reviewed by literatures.
RESULTSA clonal population of B lymphocytes with typical characteristics of immunophenotype was identified in the patient. After treated with intrathecal chemotherapy, the patient returned to normal cells count of cerebrospinal fluid and normal neurologic status. Previous studies also have demonstrated the efficacy of intrathecal chemotherapy.
CONCLUSIONCNS invasion is a rare complication of CLL. Early detection and treatment may result in better outcomes.