Expression of miR-224 in diffuse large B cell lymphoma and its clinical significance.
- Author:
Guoqi SONG
1
;
Ling GU
1
;
Bangshun HE
1
;
Yuqin PAN
1
;
Shukui WANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Lymphoma, Large B-Cell, Diffuse; metabolism; pathology; Male; MicroRNAs; metabolism; Middle Aged; Prognosis; Young Adult
- From: Chinese Journal of Hematology 2014;35(7):619-622
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of miR-224 in diffuse large B cell lymphoma (DLBCL) and its relationship with clinical pathological features and prognosis.
METHODSReal-time PCR was used to detect the expression of miR-224 in 168 DLBCL and 25 normal lymphoid tissues.
RESULTSThe expression of miR-224 in DLBCL (0.97 ± 0.33) was significantly lower than that in normal lymphoid tissues (1.87 ± 0.43, P<0.05). There were no significant correlations between the miR-224 expression and age (P=0.434), gender (P=0.613) tumors stage (P=0.250), IPI (P=0.355) and lactate dehydrogenase (P=0.398). Using the median of miRNA-224 expression as threshold, we subdivided patients into low and high expression group. The five-year progression-free survival and overall survival were significantly lower in low expression group as compared to those in high expression group.
CONCLUSIONmiR-224 expression may play an important role in the development and progression of DLBCL and could be prognostic significance.
