Guillain-Barre syndrome after allogeneic hematopoietic stem cell transplantation: two cases report and literature review.
- Author:
Xiaoqian XU
1
;
Lin JIA
1
;
Li CHEN
1
;
Weiping ZHANG
1
;
Jianmin WANG
1
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Guillain-Barre Syndrome; etiology; Hematopoietic Stem Cell Transplantation; adverse effects; Humans; Male; Postoperative Complications; Prognosis; Young Adult
- From: Chinese Journal of Hematology 2014;35(8):694-697
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical characteristics, treatment and prognosis of Guillain-Barre syndrome (GBS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
METHODSTwo cases with GBS after allo-HSCT were admitted to our hospital and a review of literatures concerning GBS developed after allo-HSCT. The clinical characteristics, treatment and prognosis were investigated.
RESULTSTwo patients experienced sensory disturbance and progressive muscle weakness 2 months after HSCT. The diagnosis of GBS was established after cranial MRI, lumbar puncture and EMG. Both patients died of GBS progression even after the treatment of steroid, intravenous immunoglobulin (IVIG) and plasma exchange.
CONCLUSIONGBS was a rare complication after allo-HSCT. The common clinical practices in treating GBS included IVIG and plasma exchange. Due to the primary malignant disease and low immunity posttransplant, infection, GVHD and other complications, prognosis of GBS was poor with high mortality.
