Clinicopathologic features of delayed radiation-induced brain injury after radiotherapy for brain tumor.
- Author:
Xing-fu WANG
1
;
Sheng ZHANG
;
Yu-hong YE
;
Yu-peng CHEN
;
Xue-yong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Brain Neoplasms; radiotherapy; Female; Glioma; radiotherapy; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; metabolism; Magnetic Resonance Imaging; Male; Middle Aged; Radiation Injuries; diagnosis; diagnostic imaging; metabolism; pathology; surgery; Radiotherapy; adverse effects; Tomography, X-Ray Computed
- From: Chinese Journal of Pathology 2012;41(4):224-228
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic features of delayed radiation-induced brain injury after radiotherapy for brain tumor.
METHODSThe clinical, histopathologic and immunohistochemical features of 9 cases with delayed radiation-induced injury were evaluated.
RESULTSThe disease occurred from 6 months to 12 years after radiotherapy and often presented with headache and muscle weakness. Magnetic resonance imaging showed peripheral enhancing lesions with slight mass effect and surrounding edema. Microscopically, the major changes included coagulative necrosis, fibrinoid necrosis of vessels, vascular hyalinization with luminal stenosis and peripheral reactive gliosis. Immunostaining for hypoxia-inducible factors 1α was positive in reactive astrocytes.
CONCLUSIONSDelayed radiation-induced brain injury is a relatively common complication of radiation therapy. The lesion was frequently misdiagnosed as brain tumor. Correct diagnosis relies on clinical, radiologic and pathologic correlation.
