Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic study.
- Author:
Wei SANG
1
;
Chao-fu WANG
;
Yu-fan CHENG
;
Xia LIU
;
Xin-xia LI
;
Abulajiang GULINAR
;
Jun-zhi LI
;
Wei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Bleomycin; therapeutic use; CD56 Antigen; metabolism; Cyclophosphamide; therapeutic use; Dendritic Cells; metabolism; pathology; Diagnosis, Differential; Doxorubicin; therapeutic use; Female; Follow-Up Studies; Hematologic Neoplasms; drug therapy; metabolism; pathology; Humans; Interleukin-3 Receptor alpha Subunit; metabolism; Leukemia, Myeloid; metabolism; pathology; Lymphoma, Extranodal NK-T-Cell; metabolism; pathology; Lymphoma, T-Cell, Peripheral; metabolism; pathology; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; metabolism; pathology; Prednisone; therapeutic use; Skin Neoplasms; drug therapy; metabolism; pathology; Treatment Outcome; Vincristine; therapeutic use
- From: Chinese Journal of Pathology 2012;41(5):326-330
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic features and differential diagnosis of blastic plasmacytoid dendritic cell neoplasm.
METHODSThe clinical, morphology and immunophenotypic features were analyzed in 3 cases of blastic plasmacytoid dendritic cell neoplasm, with review of literature.
RESULTSThe pathologic changes of these tumors accorded with that of blastic plasmacytoid dendritic cell neoplasm, and they also had new characteristics, including lineage other than T, B, myeloid and NK cells, and immunophenotypes of CD56(+) CD4(-) CD123(+) TdT(+) CD43(+) CD68(+) , CD56(+) CD4(+) CD123(-) TdT(+) CD43(+) CD68(-) and CD56(+) CD4(+) CD123(-/+) TdT(-) CD43(+) CD68(+) in the 3 cases, respectively. Bone marrow involvement was found 5 years later in case 1, and was then stable after chemotherapy; case 2 and case 3 were died 5 and 2 months after diagnosis, respectively.
CONCLUSIONBlastic plasmacytoid dendritic cell neoplasm is a heterogeneous group of lymphoproliferative disorders, with different clinical, morphologic and immunophenotypic features.
