Feasibility and value of quantitative dynamic contrast enhancement MR imaging in the evaluation of sinonasal tumors.

Junfang Xian; Huarui DU; Xinyan Wang; Fei Yan; Zhengyu Zhang; Hui Hao; Bo Zhao; Yajian Tong; Jue Zhang; Demin Han

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Feasibility and value of quantitative dynamic contrast enhancement MR imaging in the evaluation of sinonasal tumors.

Author: Junfang XIAN ^{1
,

2} ; Huarui DU ³ ; Xinyan WANG ⁴ ; Fei YAN ⁴ ; Zhengyu ZHANG ⁴ ; Hui HAO ⁴ ; Bo ZHAO ⁴ ; Yajian TONG ⁴ ; Jue ZHANG ³ ; Demin HAN ⁵
Author Information

1. Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
2. Beijing Key Laboratory of Nasal Diseases, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
3. College of Engineering, Peking University, Beijing 100871, China.
4. Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
5. Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Email: zhangjue@pku.edu.cn.
Publication Type:Journal Article
MeSH: Contrast Media; Female; Humans; Image Enhancement; methods; Magnetic Resonance Imaging; methods; Male; Middle Aged; Paranasal Sinus Neoplasms; diagnosis
From: Chinese Medical Journal 2014;127(12):2259-2264
CountryChina
Language:English
Abstract:
BACKGROUNDQuantitative dynamic contrast enhancement MR imaging (DCE-MRI), used to measure properties of tissue microvasculature and tumor angiogenesis, is a promising method for distinguishing benign and malignant tumors and characterizing tumor response to antiangiogenic treatment. The aim of this study was to assess the feasibility of quantitative parameters derived from clinically used DCE-MRI for distinguishing benign from malignant tumors in the sinonasal area, which may be potentially useful for prediction and monitoring of treatment response to chemoradiotherapy of sinonasal tumors.
METHODSOne hundred and forty-three patients with sinonasal tumors, including 78 malignant tumors and 65 benign tumors and tumor-like lesions, underwent clinically used DCE-MRI. Parametric maps were obtained for quantitative parameters including K(trans), kep and ve. Two radiologists reviewed these maps and measured K(trans), kep and ve in the tumor tissue. Data were analyzed using independent T-test or Mann-Whitney U test analysis and receiver operating characteristic curves.
RESULTSK(trans), kep and ve showed significant differences between benign and malignant tumors in the sinonasal area (P = 0.000 1). The accuracy of K(trans), kep and ve in differentiation between benign and malignant sinonasal tumors were 72.0%, 76.2% and 67.1%, respectively. There were significant differences in kep and ve between malignant epithelial sinonasal tumors and lymphomas (P < 0.05). Using a ve value of 0.213 as the threshold value differentiated malignant epithelial tumors from lymphomas with an accuracy of 78.3%, sensitivity of 88.2%, specificity of 68.0%, positive predictive value of 66.7%, and negative predictive value of 90.9%. However, no significant difference in K(trans) and kep was found between malignant epithelial and non-epithelial tumors in the sinonasal area (P > 0.05).
CONCLUSIONSIt is feasible that quantitative parameters of tumors can be derived from clinically used DCE-MRI in the sinonasal region. Preliminary findings suggest an increased value for quantitative DCE-MRI in the evaluation of sinonasal tumors in clinical practice.