Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenström macroglobulinemia.

Shuhua YI; Rui Cui; Zengjun LI; Gang AN; Junyuan QI; Dehui Zou; Peihong Zhang; Huishu Chen; Jianxiang Wang; Hong Chang; Lugui Qiu

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Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenström macroglobulinemia.

Author: Shuhua YI ¹ ; Rui CUI ² ; Zengjun LI ¹ ; Gang AN ¹ ; Junyuan QI ¹ ; Dehui ZOU ¹ ; Peihong ZHANG ¹ ; Huishu CHEN ³ ; Jianxiang WANG ¹ ; Hong CHANG ¹ ; Lugui QIU ⁴
Author Information

1. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
2. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China. Department of Hematology, Tianjin First Center Hospital, Tianjin 300192, China.
3. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
4. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China. Email: drqiu99@medmail.com.cn.
Publication Type:Journal Article
MeSH: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Prognosis; Risk Factors; Waldenstrom Macroglobulinemia; diagnosis; mortality
From: Chinese Medical Journal 2014;127(12):2327-2331
CountryChina
Language:English
Abstract:
BACKGROUNDWaldenström macroglobulinemia (WM) is an uncommon lymphoid malignancy. The characteristics and prognosis of WM have never been systematically studied in the East.
METHODSWe analyzed the clinical characteristics and the prognostic factors of 90 Chinese WM patients, and compared them with the Western reports.
RESULTSThe median age was 62 years old with a male-to-female ratio of 3.74. The most common symptoms at diagnosis were fatigue (77.8%) and bleeding (20%), while only 6 patients (6.7%) were asymptomatic. In the univariate analysis, age >62 years, thrombocytopenia, leucopenia, cytopenias ≥ 2, and high risk on the international prognostic scoring system for WM were the adverse risk factors, but only age >62 years and ≥ 2 cytopenias were the independent prognostic factors in the multivariate analysis. Using age <62 years and ≥ 2 cytopenias, three significantly different prognostic groups could been distinguished, with 5-year overall survival of 71.6%, 48.6%, and 17.0% (P < 0.001).
CONCLUSIONDistinct characteristics exist in WM in China compared to the West and we describe a new simple prognostic model for newly diagnosed WM patients.