Preliminary study on the evaluation of Langerhans cell histiocytosis using F-18-fluoro-deoxy-glucose PET/CT.

Wenlan Zhou; Hubing WU; Yanjiang Han; Shaobo Wang; Ye Dong; Quanshi Wang

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Preliminary study on the evaluation of Langerhans cell histiocytosis using F-18-fluoro-deoxy-glucose PET/CT.

Author: Wenlan ZHOU ¹ ; Hubing WU ¹ ; Yanjiang HAN ¹ ; Shaobo WANG ² ; Ye DONG ¹ ; Quanshi WANG ³
Author Information

1. Nanfang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
2. Department of Radiology, the First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, China.
3. Nanfang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Email: wqslph@163.net.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Child; Child, Preschool; Fluorodeoxyglucose F18; Histiocytosis, Langerhans-Cell; diagnosis; Humans; Middle Aged; Positron-Emission Tomography; methods; Young Adult
From: Chinese Medical Journal 2014;127(13):2458-2462
CountryChina
Language:English
Abstract:
BACKGROUNDLimited number of studies have been reported regarding the utilization of F-18-fluoro-deoxy-glucose (F-18-FDG) positron emission tomography/computed tomography (F-18-FDG PET/CT) in Langerhans cell histiocytosis (LCH). The aim of this study was to assess the role of F-18-FDG PET/CT in the diagnosis and treatment of LCH.
METHODSEight newly diagnosed and seven recurrent patients with LCH received F-18-FDG PET/CT scans. The diagnosis of LCH was established by pathology, multi-modality imaging, and clinical follow-up.
RESULTSF-18-FDG PET/CT was positive in 14 patients with 13 true positives and one false positive. All 45 LCH lesions were F-18-FDG avid including six small bone lesions <1.0 cm in diameter. The mean maximal standardized uptake value (SUVmax) was 7.13 ± 4.91. F-18-FDG uptake showed no significant difference between newly diagnosed lesions vs recurrent lesions (SUVmax: 6.50 ± 2.97 vs. 7.93 ± 6.60, t = -0.901, P = 0.376). Among 45 LCH lesions, 68.9% (31/45) were found in bones and 31.1% (14/45) in soft tissue. The most commonly involved bones were the pelvis and vertebrae. There was no significant difference in F-18-FDG uptake between bone lesions vs. non-bone lesions (SUVmax: 6.30 ± 2.87 vs. 8.97 ± 7.58, t = 1.277, P = 0.221). In two patients, changes in F-18-FDG uptake on serial PET/CT scans reflected response of lesions to treatment.
CONCLUSIONSThe present study suggests that F-18-FDG PET/CT may be useful for diagnosis and assessing the treatment response of LCH. Because of the small sample size, further research is warranted to confirm our findings.