Research progress on periventricular white matter damage pathogenesis in preterm infants.
- Author:
Wen-Ting ZHAO
1
;
Hui-Min YU
Author Information
1. Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Cerebrovascular Circulation;
Cytokines;
physiology;
Excitatory Amino Acids;
toxicity;
Humans;
Infant, Newborn;
Infant, Premature;
Leukomalacia, Periventricular;
classification;
etiology;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2013;15(5):396- following 400
- CountryChina
- Language:Chinese
-
Abstract:
Periventricular white matter damage is one of the characteristics of brain damage in preterm infants, and it is the most important type of encephalopathy. The pathological changes including the white matter of coagulation necrosis, oligodendrocyte damage, myelin damage, axonal injury and reactive gliosis and microglia infiltration in necrotic areas. All of these lesions are closely related to the nervous system sequelae in later-neonatal period. The pathogenesis of periventricular leukomalacia in premature infants are mainly cause by its immature brain vascular, and precursor oligodendrocytes of the attack of hypoxia, ischemia, infection, oxygen free radicals, inflammatory cytokines, increasing glutamate, and other high-risk factors. In this paper, an overview of progress in the study of the pathogenesis of periventricular white matter damage in premature infants through literature review to provide a theoretical support for clinical prevention, diagnosis and treatment.
