Association between MAOA-u VNTR polymorphism and its interaction with stressful life events and major depressive disorder in adolescents.
- Author:
Jing MA
1
;
Shun-Ying YU
;
Shan LIANG
;
Jun DING
;
Zhe FENG
;
Fan YANG
;
Wei-Jia GAO
;
Jia-Ni LIN
;
Chun-Xiang HUANG
;
Xue-Jun LIU
;
Lin-Yan SU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Depressive Disorder, Major; genetics; Female; Gene-Environment Interaction; Genotype; Humans; Life Change Events; Logistic Models; Male; Minisatellite Repeats; Monoamine Oxidase; genetics; Polymorphism, Genetic
- From: Chinese Journal of Contemporary Pediatrics 2013;15(7):563-568
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether the genetic polymorphism, upstream variable number of tandem repeats (uVNTR), in the monoamine oxidase A (MAOA) gene, is associated with major depressive disorder (MDD) in adolescents and to test whether there is gene-environment interaction between MAOA-uVNTR polymorphism and stressful life events (SLEs).
METHODSA total of 394 Chinese Han subjects, including 187 adolescent patients with MDD and 207 normal students as a control group, were included in the study. Genotyping was performed by SNaP-shot assay. SLEs in the previous 12 months were evaluated. The groups were compared in terms of the frequency distributions of MAOA-uVNTR genotypes and alleles using statistical software. The binary logistic regression model of gene-environment interaction was established to analyze the association of the gene-environment interaction between MAOA-u VNTR genotypes and SLEs with adolescent MDD.
RESULTSThe distribution profiles of MAOA-u VNTR genotypes and alleles were not related to the onset of MDD, severity of depression, comorbid anxiety and suicidal ideation/behavior/attempt in adolescents. The gene-environment interaction between MAOA-u VNTR genotypes and SLEs was not associated with MDD in male or female adolescents.
CONCLUSIONSIt is not proven that MAOA-u VNTR polymorphism is associated with adolescent MDD. There is also no gene-environment interaction between MAOA-u VNTR polymorphism and SLEs that is associated with adolescent MDD.