Pharmacokinetics of beta-asarone in rats.
- Author:
Hong-bin WU
1
;
Yong-qi FANG
Author Information
- Publication Type:Journal Article
- MeSH: Acorus; chemistry; Administration, Oral; Animals; Anisoles; administration & dosage; isolation & purification; pharmacokinetics; Area Under Curve; Blood-Brain Barrier; Brain; metabolism; Chromatography, High Pressure Liquid; methods; Female; Half-Life; Male; Plant Roots; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Tissue Distribution
- From: Acta Pharmaceutica Sinica 2004;39(10):836-838
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the pharmacokinetics of beta-asarone in rats.
METHODSThe concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system.
RESULTSThe pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum.
CONCLUSIONThe absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.
