Synthesis and antibacterial activity of ciprofloxacin derivatives.
- Author:
Fa-qing YE
1
;
You-mei DING
;
Li CHEN
;
Song YE
;
Zhi-xiang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Infective Agents; chemical synthesis; chemistry; pharmacology; Ciprofloxacin; analogs & derivatives; chemical synthesis; chemistry; pharmacology; Escherichia coli; drug effects; Female; Mice; Molecular Structure; Nitroimidazoles
- From: Acta Pharmaceutica Sinica 2005;40(2):132-135
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the synthesis and antibacterial activity of ciprofloxacin derivatives.
METHODSCiprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested.
RESULTSNine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis.
CONCLUSIONCompounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.
