Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists.
- Author:
Chao-bin ZHONG
1
;
Xue-jun ZHU
;
Zhong-rong LIU
;
Xiao-ping GAO
;
Xue-chao WANG
Author Information
- Publication Type:Journal Article
- MeSH: 3T3-L1 Cells; Animals; Glucose; metabolism; Hypoglycemic Agents; agonists; chemical synthesis; pharmacology; Insulin; pharmacology; Isoxazoles; chemical synthesis; pharmacology; Mice; PPAR gamma; agonists; chemical synthesis; pharmacology
- From: Acta Pharmaceutica Sinica 2005;40(2):136-140
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo find new peroxisome proliferator-activated y agonists with high activity and low toxicity.
METHODSBased on JTT-501 and JTT-20993, new isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds were designed and synthesized. Their insulin-sensitizing activities were evaluated.
RESULTSEight new compounds were obtained. The structures of synthesized compounds were characterized by NMR, MS and IR. Four compounds (1A-4A) showed insulin-sensitizing activities.
CONCLUSIONCompounds (1A and 3A) showed excellent insulin-sensitizing activities and should be worth further investigation.
