Metabolic pathways of dipfluzine in rats.
- Author:
Hui-chen LIU
1
;
Yu-min DU
;
Yong-li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Benzophenones; urine; Chromatography, Liquid; Cinnarizine; analogs & derivatives; metabolism; urine; Female; Gas Chromatography-Mass Spectrometry; Glucuronides; urine; Male; Rats; Rats, Wistar
- From: Acta Pharmaceutica Sinica 2005;40(2):168-172
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the metabolic pathways of dipfluzine in rats.
METHODSAfter an oral dose of dipfluzine (80 mg x kg(-1)) to rats, urine was collected for 12 h. The metabolites of dipfluzine in urine were chromatographed and identified by LC/DAD/MS methods.
RESULTSIn the rat urine, there were 1-(4-fluorophenyl)-4-piperazinylbutanone and its glucuronide, 4-hydroxybenzophenone and its glucuronide, 4-fluoro-gamma-hydroxybenzenebutanoic acid and its glucuronide and sulfate, diphenylmethanol and its glucuronide, dipfluzine, and benzophenone.
CONCLUSIONIn rats, dipfluzine was mainly metabolized in the pathways of N-desalkylation at 1- and 4-positions of piperazine ring. Some of metabolites were further conjugated with glucuronic acid and/or sulfuric acid.
