Effect of iontophoresis on skin permeation of defibrase.
- Author:
Hui-ying ZHAO
1
;
Qi-peng YUAN
;
Jun-min ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Batroxobin; administration & dosage; pharmacokinetics; Epidermis; metabolism; Fibrinolytic Agents; administration & dosage; pharmacokinetics; Humans; Hydrogen-Ion Concentration; Iontophoresis; Rats; Rats, Wistar; Skin Absorption
- From: Acta Pharmaceutica Sinica 2005;40(2):178-181
- CountryChina
- Language:English
-
Abstract:
AIMTo investigate the effect of iontophoresis on skin permeation of defibrase.
METHODSIontophoresis was carried out in side-by-side chambers, excised rat skin membrane (RSM) or human epidermis membrane (HEM). The effects of electrode polarity, permeation medium pH and ionic strength were evaluated.
RESULTSPermeation of defibrase caused by anodal iontophoresis was more effective [the apparent permeability coefficient was (1.2 +/- 0.4) x 10(-4) cm x h(-1)] than that of cathodal iontophoresis [(4.3 +/- 1.4) x 10(-5) cm x h(-1)]. The amount of permeated defibrase caused by anodal iontophoresis in pH 7.4 medium was (25 +/- 5) x 10(-14) mol x cm(-2), which was higher than that of in pH 6. 4 permeation medium [(15 +/- 4) x 10(-14) mol x cm(-2)].
CONCLUSIONIontophoresis could enhance skin permeation of defibrase. Electroosmotic flow effect played an important role.
